Defined terms clause samples

Appendix 3B New issue announcement 6g If securities issued under rule 7.1A, was issue price at least 75% of 15 day VWAP as calculated under rule 7.1A.3? Include the issue date and both values. Include the source of the VWAP calculation. 6h If securities were issued under rule 7.1A for non-cash consideration, state date on which valuation of consideration was released to ASX Market Announcements 6i Calculate the entity’s remaining issue capacity under rule 7.1 and rule 7.1A – complete Annexure 1 and release to ASX Market Announcements Dates of entering +securities into uncertificated holdings or despatch of certificates 7 Number and +class of all +securities quoted on ASX (including the securities in section 2 if applicable) 8 9 Number and +class of all +securities not quoted on ASX (including the securities in section 2 if applicable) Rights at $0 , exp. Rights at $0 , exp. + See chapter 19 for defined terms. 01/08/2012 ACTIVE 43333674v1 Appendix 3B Page 3 Number +Class 5,000,000 5,000,000 10,500,000 12,500,000 15,500,000 26,250,000 25,000,000 25,000,000 Options at $0.02, exp. 24/11/20 (GTGAD) Options at $0.02, exp. 31/3/21 (GTGAD) Options at $0.01, exp. 16/2/22 (GTGAD) Options at $0.0153, exp. 8 August 2021 Options at $0.01, exp. 11/12/21 Class A - Performance Rights at $0 , exp. 11/12/21 Class B - Performance 11/12/21 Class C - Performance 11/12/21 Number +Class 2,716,712,693 Ordinary shares 6 May 2019 7.1: 187,784,273 7.1A: 191,814,713 Not applicable Issue price of $0.00676 per share is greater than 75% of the 15 day VWAP of $0.00694 as calculated under Listing Rule 7.1A.3. The shares were issued on 6 May 2019. The source data for the VWAP calculation was obtained from IRESS.

6e Number of +securities issued with security holder approval under rule 7.3, or another specific security holder approval (specify date of meeting) Number of +securities issued under an exception in rule 7.2 6f If +securities issued under rule 7.1A, was issue price at least 75% of 15 day VWAP as calculated under rule 7.1A.3? Include the +issue date and both values. Include the source of the VWAP calculation. 6g If +securities were issued under 6h rule 7.1Afornon-cash consideration,statedateon which valuation of consideration was released to ASX Market Announcements 6i Calculate the entity’s remaining issue capacity under rule 7.1 and rule 7.1A – complete Annexure 1 and release to ASX Market Announcements +Issue dates Note: The issue date may be prescribed by ASX (refer to the definition of issue date in rule 19.12). For example, the issue date for a pro rata entitlement issue must comply with the applicable timetable in Appendix 7A. Cross reference: item 33 of Appendix 3B. 7 8 Numberand+classofall +securitiesquoted on ASX (includingthe+securitiesin section 2 if applicable) + See chapter 19 for defined terms. 04/03/2013 Appendix 3B Page 3 Number +Class Number +Class 4,063,134,143 Fully paid ordinary shares 20 December 2019 Refer Annexure 1 N/A N/A N/A 250,000,000 unlisted options.

Appendix 3Y Change of Director’s Interest Notice issue as approved by shareholder under Part 2 – Change of director’s interests in contracts Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part. Irwin Biotech Nominees Pty Ltd <BIO A/C> + See chapter 19 for defined terms. 01/01/2011 Appendix 3Y Page 3 Detail of contract Sub-underwriting Agreement Nature of interest Indirect Name of registered holder (if issued securities) RIP Opportunities Pty Ltd <PIR Super Fund A/C> Date of change 20 December 2019 No. of securities held after change Irwin Biotech Nominees P/L <BIO A/C> 6,200,000 ordinary shares Irwin Biotech Nominees Pty Ltd <BIO A/C> 80,849,310 ordinary shares 5,000,000 Performance Rights Irwin Biotech Nominees Pty Ltd 2,000,000 ordinary shares Irwin Biotech Nominees Pty Ltd 26,582,700 ordinary shares (represented by 44,305 American Depositary Receipts) RIP Opportunities Pty Ltd 7,500,000 ordinary shares (represented by 12,500 American Depositary Receipts) RIP Opportunities Pty Ltd <PIR Super Fund A/C> 124,999,999 ordinary shares 125,000,000 Unlisted Options Nature of change Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back Unlisted Options issued pursuant to the sub-underwritingofnon-renounceablerights Resolution 6 at the Company’s Annual General Meeting held on 28 November 2019.

Appendix 3Y Change of Director’s Interest Notice underwritingofnon-renounceable rights Part 2 – Change of director’s interests in contracts Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part. + See chapter 19 for defined terms. Appendix 3Y Page 2 01/01/2011 Detail of contract Sub-underwriting Agreement Nature of interest Indirect Name of registered holder (if issued securities) MJGD Nominees Pty Ltd Date of change 20 December 2019 Class Unlisted options with an exercise price of $0.008 per option, expiring 29 October 2022 (Unlisted Options). Number acquired 125,000,000 Unlisted Options Number disposed Nil Value/Consideration Note: If consideration is non-cash, provide details and estimated valuation Nil No. of securities held after change MJGD Nominees Pty Ltd 207,103,424 ordinary shares JGM Investment Group (The Muchnicki Family A/C) 9,400,000 ordinary shares 125,000,000 Unlisted Options MJGD Nominees Pty Ltd (BSMI A/C) 4,849,129 ordinary shares 6,250,000 Performance Rights Nature of change Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back Unlisted Options issued pursuant to the sub-issue as approved by shareholder under Resolution 6 at the Company’s Annual General Meeting held on 28 November 2019.